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Endurance trained men who took a ketone monoester alongside caffeine before 90 minutes of loaded walking in the heat lasted 8.9 minutes in a following run to exhaustion, against 7.0 minutes on an energy matched carbohydrate drink, and held their accuracy on the easier of two working memory tasks. Core temperature and heart rate were the same either way.
Journal of the International · Lints et al. · University of South Carolina · 16 July 2026 · PMID 42460838
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